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But, lycopene within complement shape doesn’t look like effective at decrease doses, either.

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“There is a sturdy [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the prevalence of certain cancers.” But whilst we complement with only a unmarried compound remoted within pill shape, we may also upset the healthful natural stability of antioxidants. It does appear to be pretty the human hubris to assume we can reproduce “the useful consequences of consuming entire fruits and veggies” by giving dietary supplements of a single phytochemical, which could usually interact with hundreds of different compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are recognized “to build up within human prostate tissue.” And, “there are also severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—no longer to mention all the compounds we've yet to even characterize.

But, it’s now not about finding the only magic bullet: “The anti-most cancers results of carotenoids and other phytonutrients may live within [their] combined pastime.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within most of the people who eat everyday quantities of tomatoes, there’s very little impact on most cancers cell boom within vitro, used one after the other.

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But integrate all of them together, and a non-powerful dose plus a non-effective dose becomes powerful somehow, substantially suppressing prostate cancer cellular growth.

And, the identical synergy may be visible throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E found in nuts and seeds do little to inhibit seasoned-growth signaling of prostate cancer cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The complete is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA levels dropped “by means of 17.5%.” PSA, prostate-specific antigen, is a protein produced via prostate gland cells, and expanded blood levels are routinely used “to reveal the fulfillment of [cancer] treatment.

It turned into sudden to discover that,” in just three weeks, a “tomato sauce-based dietary intervention” should lower PSA concentrations within men with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped via 21%.

Imagine how antioxidant-terrible their food regimen have to were ahead, if much less than a cup of tomato sauce a day should reduce DNA damage by way of extra than a 5th.

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Okay, however what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be especially prone to oxidative DNA harm through unfastened radicals, which can be idea to play a crucial role in all levels of [cancer formation].” This can be for some of reasons, inclusive of “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical damage than predicted.

Here’s the DNA damage within the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here become no association among” the extent of lycopene in the prostate and the protective outcomes.

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Tomatoes comprise a whole bunch of factors, some of which may be even extra powerful than lycopene.

Regardless, in contrast to the lycopene dietary supplements by myself, “the entire-food intervention” regarded to help. To see if lycopene performed any role in any respect, one would have to test a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what in case you in comparison pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene in a pill?

So, they fed people pink tomato paste, yellow tomato paste, lycopene pills, or placebo drugs, and then dripped their blood on prostate most cancers cells developing in a petri dish.

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Compared to the ones not ingesting some thing, the pink tomato serum, the blood from those who ate crimson tomato paste, drastically reduced the prostate most cancers mobile’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by the pink tomato consumption “may also make contributions to decrease prostate most cancers chance through restricting cell proliferation.” The red tomato appeared to work better than the yellow;

so, maybe the lycopene helped, however now not within tablet form. “[T]his gene turned into no longer regulated by way of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene on my own appreciably upregulated “procarcinogenic genes.

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