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But, lycopene in complement shape doesn’t look like powerful at decrease doses, both.

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“There is a robust [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the occurrence of certain cancers.” But while we complement with best a single compound isolated in tablet shape, we may additionally dissatisfied the wholesome natural stability of antioxidants. It does appear to be quite the human hubris to think we will reproduce “the beneficial consequences of eating whole end result and vegetables” by giving dietary supplements of a unmarried phytochemical, which could normally have interaction with heaps of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are acknowledged “to build up within human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—no longer to mention all the compounds we have yet to even symbolize.

But, it’s not approximately locating the one magic bullet: “The anti-cancer consequences of carotenoids and other phytonutrients may reside in [their] blended hobby.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed in most of the people who devour normal amounts of tomatoes, there’s little or no effect on most cancers cellular increase within vitro, used one by one.

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But integrate them all together, and a non-powerful dose plus a non-effective dose becomes powerful by some means, considerably suppressing prostate most cancers cell growth.

And, the identical synergy can be seen across foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the nutrition E located in nuts and seeds do little to inhibit seasoned-boom signaling of prostate cancer cells—much less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “via 17.5%.” PSA, prostate-unique antigen, is a protein produced by prostate gland cells, and improved blood ranges are robotically used “to monitor the achievement of [cancer] treatment.

It become sudden to locate that,” in only three weeks, a “tomato sauce-based dietary intervention” ought to lower PSA concentrations within men with prostate most cancers. Also, free radical damage of the DNA of their white blood cells dropped through 21%.

Imagine how antioxidant-poor their diet have to were ahead, if much less than a cup of tomato sauce a day could reduce DNA damage by way of extra than a 5th.

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Okay, but what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be specially vulnerable to oxidative DNA damage by means of unfastened radicals, which might be concept to play a essential function within all levels of [cancer formation].” This can be for a number of reasons, consisting of “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% much less loose radical harm than anticipated.

Here’s the DNA harm in the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here was no affiliation between” the level of lycopene in the prostate and the protecting outcomes.

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Tomatoes comprise an entire bunch of things, some of which may be even greater effective than lycopene.

Regardless, within comparison to the lycopene dietary supplements on my own, “the whole-meals intervention” seemed to assist. To see if lycopene performed any position in any respect, one might have to test a lycopene-unfastened tomato—within different phrases, a yellow tomato.

So, what in case you compared pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to immediately lycopene within a tablet?

So, they fed people pink tomato paste, yellow tomato paste, lycopene tablets, or placebo drugs, and then dripped their blood on prostate cancer cells growing in a petri dish.

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Compared to the ones now not consuming anything, the crimson tomato serum, the blood from folks who ate crimson tomato paste, significantly reduced the prostate cancer cellular’s expression of a growth-promoting gene called cyclin D1.

This downregulation of the gene via the red tomato intake “may additionally make a contribution to lower prostate most cancers danger by way of restricting mobile proliferation.” The red tomato seemed to work better than the yellow;

so, maybe the lycopene helped, however no longer in tablet shape. “[T]his gene turned into not regulated by means of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone notably upregulated “procarcinogenic genes.

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