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Where Did That Even Come From?

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In the 80s, a crew of respected Norwegian researchers suggested a peculiar finding. They were evaluating the urine of autistic kids to the urine of everyday children, within hope of teasing out any differences that might result in recommendations as to what the cause is.

This is a urine profile, which indicates spikes for every of the various components.

This is what normal urine comes out like, with the peptides location pretty quiet. (Peptides are like small portions of proteins, and generally, we shouldn’t be peeing out an awful lot protein).

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But that is the urine profile from a child with autism, with all sorts of peptide spikes.

Here’s any other one. This raised the query:

“Can the Pathophysiology [the dysfunction] of Autism be Explained by way of the Nature of the[se] Discovered Urine Peptides?” First, they needed to answer:

“Where do the peptides come from?” They didn’t recognize.

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But, there was a clue:

most of the parents of autistic children said that they were given worse after they have been exposed to cow’s milk.

Huh? Well, there are these two proteins:

gluten, a protein in wheat, and casein, a protein within milk, that destroy down no longer most effective into peptides, but exorphins.

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Exorphins are “opioid peptides derived from food proteins”—”referred to as exorphins…due to their exogenous beginning [meaning from outside of the body] and morphine-like activity,” instead of endorphins, which are morphine-like compounds we produce internal our our bodies. So, perhaps a number of those food peptides represent like “A New Class of Hormones?” So, is that what the youngsters were peeing out?

Apparently so, as a number of those peptides had opioid hobby.

Okay. So, perhaps they have been onto some thing.

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There are “[t]wo forms of opioids [that] had been observed within milk.” One is the “casomorphins in view of their morphine-like activity and their origin.” They are breakdown products, fragments of the milk protein casein.

What’s the alternative one? The other opioid is the actual opiate:

morphine.

There appears to be actual morphine in milk.

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This can’t simply be a coincidence.

“It is [hard] to believe that these, or other sorts of opioids found inside the milk, are with out physiological or nutritional significance.” And, think about it;

it makes general experience. “Morphine and the opioid peptides may additionally…have an crucial role inside the mom-toddler bond…” We need babies to be “’addicted’ to their personal mother’s milk.” Okay.

But, what approximately the milk of another species?

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“Human [breast] milk is markedly unique from that of other…species [in that it] has the bottom” casein content material, and human casein is a markedly special protein within terms of its sequence of amino acid building blocks. Human milk has 15 instances much less casein than bovine milk, and differs collection-wise by approximately 1/2, and so breaks down into peptides differently.

Twenty-one bioactive peptides had been recovered from cow casein, together with a couple of casomorphins, in comparison to simplest five energetic peptides diagnosed in human milk, and simplest one casomorphin.

And, the casomorphins “from bovine casein are stronger.” This is a image of opioid interest, where lower means stronger. Here’s the efficiency of hetero morphine.

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