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But, lycopene within complement form doesn’t appear to be effective at decrease doses, either.

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“There is a sturdy [protective] correlation among the intake of [actual whole] fruit[s] and greens and the occurrence of positive cancers.” But whilst we complement with only a unmarried compound remoted within tablet shape, we can also dissatisfied the healthful herbal balance of antioxidants. It does appear to be quite the human hubris to suppose we can reproduce “the beneficial consequences of consuming entire end result and greens” with the aid of giving dietary supplements of a single phytochemical, which would commonly interact with hundreds of other compounds in “the herbal matrix” Mother Nature meant.

In addition to lycopene, different carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are regarded “to accumulate in human prostate tissue.” And, “there are also severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—now not to mention all the compounds we have but to even represent.

But, it’s now not about locating the only magic bullet: “The anti-most cancers consequences of carotenoids and other phytonutrients may also live within [their] mixed activity.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered in the majority who eat everyday quantities of tomatoes, there’s little or no impact on most cancers cellular growth within vitro, used one after the other.

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But integrate them all collectively, and a non-powerful dose plus a non-effective dose becomes effective by some means, considerably suppressing prostate cancer mobile increase.

And, the identical synergy may be visible throughout ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E located within nuts and seeds do little to inhibit seasoned-increase signaling of prostate cancer cells—less than 10%.

But all three together suppresses boom signaling like 70%.

The entire is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “by way of 17.5%.” PSA, prostate-unique antigen, is a protein produced by prostate gland cells, and accelerated blood tiers are routinely used “to monitor the fulfillment of [cancer] remedy.

It become unexpected to locate that,” in only three weeks, a “tomato sauce-primarily based dietary intervention” ought to decrease PSA concentrations in guys with prostate cancer. Also, unfastened radical harm of the DNA of their white blood cells dropped by using 21%.

Imagine how antioxidant-bad their food plan need to had been in advance, if less than a cup of tomato sauce an afternoon could lessen DNA harm through extra than a 5th.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be particularly vulnerable to oxidative DNA damage via free radicals, which might be concept to play a critical position in all degrees of [cancer formation].” This may be for a number of motives, together with “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% less free radical damage than expected.

Here’s the DNA harm within the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here become no association between” the level of lycopene in the prostate and the protecting effects.

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Tomatoes comprise an entire bunch of factors, some of which may be even extra powerful than lycopene.

Regardless, within assessment to the lycopene supplements alone, “the whole-meals intervention” appeared to assist. To see if lycopene played any role in any respect, one could have to test a lycopene-free tomato—within other phrases, a yellow tomato.

So, what in case you as compared purple tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to instantly lycopene in a pill?

So, they fed humans crimson tomato paste, yellow tomato paste, lycopene drugs, or placebo pills, after which dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to the ones now not ingesting some thing, the purple tomato serum, the blood from those who ate crimson tomato paste, substantially decreased the prostate most cancers cellular’s expression of a boom-selling gene referred to as cyclin D1.

This downregulation of the gene by means of the crimson tomato intake “may also make contributions to decrease prostate most cancers danger by means of restricting mobile proliferation.” The red tomato appeared to work better than the yellow;

so, perhaps the lycopene helped, but not within tablet form. “[T]his gene became now not regulated through [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone drastically upregulated “procarcinogenic genes.

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