Ham Sandwich

Mark Velov Author: Mark Velov Time for reading: ~6 minutes Last Updated: February 14, 2026
Ham Sandwich

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a unmarried genetic mutation that doubled the lifespan of a tiny roundworm.

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Instead of all being dead with the aid of 30 days, the mutants lived 60 days or longer. This lifespan extension turned into the biggest yet mentioned within any organism.

This Methuselah trojan horse clinical surprise is the equal of manufacturing a healthy 200-yr-antique human—all due to a single mutation?

That shouldn’t manifest; I mean, possibly, growing older is as a result of a couple of methods, many genes.

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How should just knocking out one gene double the lifespan?

What is this growing old gene, besides? This gene that so hastens ageing that if it’s knocked out, the animals stay twice as long?

It’s been referred to as the Grim Reaper gene.

What is it?

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It’s the trojan horse equal of the human IGF-1 receptor.

And mutations of that equal receptor within humans may additionally assist explain why some human beings live to be 100, and different people don’t.

So, Is It Just The Luck Of The Draw Whether We Got Good Genes Or Bad?

No, we can activate and off the expression of those genes, depending on what we eat.

Three years ago, I profiled a fantastic shows of experiments approximately IGF-1—insulin-like boom thing 1—this cancer-promoting boom hormone, launched in extra amounts by our liver when we consume animal protein.

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So, women and men who don’t devour meat, egg whites, or dairy proteins have extensively decrease ranges circulating within their our bodies. Switching humans to a plant-primarily based diet can considerably decrease IGF-1 tiers through simply 11 days, markedly enhancing the capability of girls’s bloodstreams to suppress breast most cancers boom, after which kill breast most cancers cells off.

Similarly, the blood serum of men on plant-primarily based diets suppresses prostate cancer mobile increase about eight instances better than before they modified their weight-reduction plan.

This dramatic development in most cancers defenses is, but, abolished if you add again simply the amount of IGF-1 banished from their systems due to the fact they had been eating and residing more healthy. This is one manner to provide an explanation for the low shares of cancer amongst plant-based populations:

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the drop within animal protein consumption ends in a drop within IGF-1, which leads to a drop within cancer increase.

An effect so effective, Dean Ornish and co-workers seemed as a way to opposite the development of prostate most cancers without chemo, surgery, or radiation—just a plant-based weight-reduction plan, and other healthful life-style changes. Now, while we’re kids, we need growth hormones to grow.

There’s an extraordinary genetic illness that causes intense IGF-1 deficiency, main to a type of dwarfism—but also seemingly makes you successfully cancer-proof.

Not a single death from most cancers within approximately 100 people with IGF-1 deficiency.

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How about 200 individuals?

None advanced most cancers.

See, maximum malignant tumors are blanketed in IGF-1 receptors. But if there’s no IGF-1 round, then they may now not be able to develop and unfold.

This can also help explain why the ones ingesting low-carb diets appear to cut their lives brief.

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But not just any low-carb food regimen—specifically the ones based on animal resources, whereas vegetable-based totally low-carb diets have been related to a decrease threat of demise. But look, low-carb diets are excessive within animal fat, in addition to animal protein.

So, how will we understand it wasn’t the saturated animal fats that was killing human beings off, and it had nothing to do with the protein?

What we need is a study that just follows some thousand human beings and their protein intakes for twenty years or so, and just see who lives longest, who gets cancer, who doesn’t. But, there’s never been a study like that—till now.

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6,000 women and men over age 50 from throughout the us of a.

had been accompanied for 18 years, and those beneath age 65 with excessive protein intakes had a 75% boom in common mortality, and a fourfold growth within the risk of dying from most cancers. But no longer all proteins;

those institutions have been both abolished or attenuated if the proteins had been plant-derived.

This all makes sense, given the better IGF-1 stages among those consuming lots of animal protein.

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 The sponsoring university despatched out a press release with a memorable establishing line:

“That chicken wing you’re consuming could be as deadly as a cigarette,” explaining that eating a weight loss program wealthy within animal proteins at some point of middle age makes you four times much more likely to die from most cancers than a person with a low-protein eating regimen—a mortality risk component corresponding to smoking cigarettes.

And while they are saying low-protein weight-reduction plan, what they honestly mean is just getting the endorsed amount of protein. “Almost everybody is going to have a most cancers cellular or pre-cancerous cellular in them at some point.

The query is:

Does it development?” said one of the lead researchers. That may additionally rely upon what we consume.

“The question isn't whether or not a sure food plan lets in you to do well within the quick term,” one of the researchers stated.

“But Can It Help You Survive To Be 100?” It Wasn’t Just More Deaths From Cancer;

middle-elderly people who eat plenty of protein from animal assets have been located to be extra liable to early death within standard.

Crucially, the equal did not follow to plant proteins, like beans.

And it wasn’t the fats, however the animal protein that appeared to be the offender. What turned into the response to the revelation that diets high within meat, eggs, and dairy might be as harmful to health as smoking?

Well, one nutrients scientist spoke back that it become probably dangerous.

It may want to damage the effectiveness of critical public fitness messages. A smoker may assume, “Why trouble quitting smoking if my ham and cheese sandwich is just as terrible for me?'” It jogs my memory of a well-known Philip Morris cigarette ad that tried to downplay the dangers by announcing, “Hey, you think 2d-hand smoke is terrible, increasing the hazard of lung cancer 19%;

properly, good day, consuming one or glasses of milk can be three instances as awful—62% increased chance of lung most cancers.

Or doubling the threat frequently cooking with oil; or tripling your hazard of heart disorder consuming non-vegetarian;

or multiplying your danger six-fold ingesting masses of meat and dairy.” So, they finish, “Let’s maintain a few attitude right here.” The risk of most cancers from secondhand smoke can be properly under that of different normal activities.  So, breathe deep.  That’s like saying:

yeah, don’t worry about getting stabbed, because getting shot is a lot worse. It’s like saying if you don’t wear seat belts, you might as well have unprotected sex.

If you move bungee leaping, might as well disconnect your smoke alarms at domestic.

Two risks don’t make a right. Of path, you’ll be aware Philip Morris stopped throwing dairy below the bus when they purchased Kraft Foods.

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