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They have been essentially denied, with the FDA pronouncing that the evidence was “very limited and initial,” without a endorsement allowed for ketchup or dietary supplements.

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By that point, similarly populace experiences had cast doubt on the lycopene principle. Consumers of excessive dietary intakes of lycopene didn’t seem to have decrease cancer shares, in any case.

But, who has high dietary intakes of lycopene?

Those that consume the maximum pizza; so, maybe it’s no surprise there are combined outcomes.

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What we need is to position lycopene to the test.

It began with a case research. A 62-year antique man with terminal prostate cancer;

failed surgical procedure, failed chemotherapy, metastases all over, spread to the bone.

And so, he changed into sent to hospice to die.

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So, he took it upon himself to initiate “phytotherapy”—plant-based totally remedy, taking the amount of lycopene found in 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a measure of tumor bulk, started out out at 365, dropped to 140 the subsequent month, and then all the way down to 8.

His metastases began disappearing, and, as of his closing comply with-up, seemed to be dwelling happily ever after. But, whilst given within higher-dose pill shape, it didn’t seem to work.

A 2013 assessment of all such lycopene supplement trials “failed to support [the initial] optimism.” In truth, they have been just glad that the lycopene capsules didn’t become inflicting extra most cancers, like beta-carotene capsules did.

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But, then got here 2014. Researchers within Italy had been giving the largest doses they might of lycopene, selenium, and remoted green tea compounds to men with precancerous prostate lesions, hoping they may save you full-blown most cancers.

But, in 2014, the improved results of a comparable trial have been published, in which selenium and vitamin E dietary supplements ended in more most cancers.

Yikes! So, those researchers stopped their trial, and broke the code to unblind the outcomes, And certainly, those taking high doses of lycopene, green tea catechins, and selenium appeared to get more most cancers than folks who just were given sugar capsules.

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“The capacity implications are dramatic,” said the lead researcher, “given the modern-day massive global use of such compounds as alleged preventive supplementations within prostate and different cancers.” What went incorrect?

Well, after the beta-carotene tablet debacle, researchers measured mobile damage at one of a kind natural and unnatural doses of beta-carotene. At nutritional doses, beta-carotene suppressed mobile damage, but at higher, supplemental doses, it not best regarded to forestall working, but brought on extra harm.

And, the same with lycopene.

“Both lycopene and [beta]-carotene afforded protection in opposition to DNA harm” on the varieties of levels one would possibly see in humans ingesting lots of tomatoes or sweet potatoes—”degrees…comparable with those visible within the [blood] of those who devour a carotenoid-wealthy healthy weight loss plan.” However, at the kind of blood concentrations that one might get taking drugs, “the ability to guard the cells against such [free radical] harm was unexpectedly misplaced, and, indeed, the presence of [high levels of beta-carotene and lycopene] may additionally without a doubt serve to increase the extent of DNA damage.” So, no wonder excessive-dose lycopene capsules didn’t paintings.

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“Phytochemicals [may be] guardians of our fitness,” however “[t]he protection of ingesting focused extracts…is unknown.” The protective benefits of a phytochemical-wealthy weight loss plan is pleasant received [through whole plant foods].” The meals industry has one-of-a-kind thoughts, even though.